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Hello out of the four motherboard options:

• Asus Prime Z270-Ahttps://www.newegg.com/Product/Product.aspx?Item=N82E16813132936 (https://www.newegg.com/Product/Product.aspx?Item=N82E16813132936)

• GIGABYTE GA-B250-FinTech (New) https://www.newegg.com/Product/Product.aspx?Item=N82E16813145052 (https://www.newegg.com/Product/Product.aspx?Item=N82E16813145052)

• ASRock H110 Pro BTC+ https://www.newegg.com/Product/Product.aspx?Item=N82E16813157781 (https://www.newegg.com/Product/Product.aspx?Item=N82E16813157781)

• ASUS B250 MINING EXPERT  https://www.newegg.com/Product/Product.aspx?Item=N82E16813119028 (https://www.newegg.com/Product/Product.aspx?Item=N82E16813119028)

Which is the better motherboard to use and why?

I just want to be able to run 12 graphic cards on one motherboard without crashes or downtime and ease of use. Whichever can help me maintain that, that's what I will buy. If any of you have had experience with any of these 4 motherboards please share your experience.

I already have an Asus Prime Z270-A and like it, but I was hoping to use something like the Gigabyte GA-250-Fintech since it's new and has 12 pcie slots so I don't need to use things like 1 to 4 pcie extensions or m.2 to pcie

I prefer ASRock, but if you're going for no. of PCI slots, go for the biggest for your sized rig and make sure the you have big RAM and the newest CPU port.
DDR5 is better (not essential though).

Mobos are the ultimate factor when building a rig so just make sure that it does what you need it to do which is have enough PCI slots and has enough RAM slots and CPU is a newer model.