I am running 4x R9 290x (HIS and Sapphire) - usually get about 3.4Mh on regular scrypt - getting 1.4Mh on scrypt-n
My changes to 'standard' settings are that I am running a TC 25051 and I-18 (usually run 28632 and I-20)
Having some issues with black screens and the rig just locking up - but when it runs it is pretty stable and stays up for most of the day (only had it running about 3 days now)