I am running two rigs with this board using 6 gpus sucessfully and soon to test with 7.

I can tell you that you won't be able to use both of the M.2 slots as you hoped because atleast 1 of the M.2 slots shared PCIe lanes with the PCIex1 #2 and #4 slots on the motherboard.
I know this because to get 6 gpu's to run correctly you have to distinctly change that setting to disable the M.2 slot in bios and use the PCIex1 #2,4 instead.
I am not positive but you may be able to use the other M.2 slot. I will double check, if so I may just order an adapter and try it out.

Edit: I am wrong, I looked up the PDF of the manual. It turns out it was the front USB 3.1 connector I had to disable in BIOS that shares bandwidth with the PCIex1 #2,4. The M.2 slots only share bandwidth with SATA 5 and 6. The M.2 adapters may very well work.
       Link to manual (Section 1.6.7):  http://dlcdnet.asus.com/pub/ASUS/mb/LGA1151/STRIX_Z270E_GAMING/E12349_Z270E_GAMING_BIOS_EM_WEB.pdf?_ga=2.219611673.1480583767.1496203431-1198207353.1492379291

Ok sounds good I will look into getting Alexis and ZPool as well. I have been diverting some hash to DGB as payouts have risen and i'm using tpruvot and Groestl at the moment. I guess my last question is how Skein/ZPool works. Skein is and algo and the prefix of coin correct? When you say you are mining Skein on ZPool are you mining a certain coin all coins that use Skein as an algorithm (like DGB). Or am I misunderstanding something about Skein?

Is there any difference between Alexis and tpruvot? I have been using tpruvot but keep hearing Alexis is used for Skein. I have two Nvidia rigs and have been looking to point them somewhere more profitible than Nicehash, especially with the upcoming increase to 4% fees. Also any tips on using ZPool? You can set up a BTC payout or get paid directly in the coin you are mining correct?

Skein algo on any coin or a specific coin? Can you point me towards a pool? I was about to order a 1080Ti for ZCash but I have been hearing about Skein as well everywhere for 1080Ti.

Agreed. I've started diverting a small percentage of my hash from nicehash to digibyte as a little investment. Wanna get some coins while block reward is still high.

I understand the reasoning, but damn 4% just sounds bad on paper. I love Nicehash and all but I might look to bring my hash elsewhere with this change.

Yeah I don't think it works like that. Wallets don't auto convert anything unless otherwise explicitly stated so I would only assume you can send DGB to your DGB address. With SuprNova I didn't have to configure a payout address in my CCMiner .bat file, it's specified in the account options of the pool's website. If you want to mine actual DGB itself you'll have to find a pool that mines DGB using one of the 5 algos DGB is compatible to mine with, of which Groestl is one.

I started mining it two days ago as well. Do you have a Digibyte wallet set up like Digibyte Core? I'm not sure on the specifics of your pool but I used SuprNova and successfully got a few thousand DGB using myriad-groestl.