Yes you can do it.
If there is a mixture of GPU series/brands in the same RIG. Usually, one or two GPUs are detected or can be detected by all GPUs. If some GPUs are not detected, then try to install drivers one by one.

Sometimes when all GPUs are detected, while running mine, there is a GPU hashrate that is down or readable 0. If that happens, try selecting the latest or compatible driver mining until all GPUs have a normal hashrate.

Good luck.

From the definition of POW and POS is different. Although you want to use POS mining. if doing POS it just speculates to get profit. that too if your coins a lot and high coins price when you want to sell it. Come on if you want mining altcoins better build RIG. it is more give hope profitable than speculate with POS.

For GPU, Suggest getting 1070.NVIDIA nice for algo EQUIHASH. When compared to VEGA FE (TDP 300 W), NVIDIA low power consumption (TDP 150 W). Also, Power Connector 1x8 PIN (1070), while VEGA FE (2x8 PIN), it, of course, can save the use of cable on the PSU.

For coins don't stick to the choice of one coin, meaning if it is a good moment to zcash. do it mining zcash, or vice versa. each person has different considerations when choosing, what coins should to be mining.

My longest coin mine is ETH. Although Network Hashrate and Diff are increasingly rising. but that's not a serious problem for me because the price of ETH converted to BTC is relatively stable and even Rise. But there are times when mining coins that have a pretty good moment for the mining like XMR, MusicCoins, BTG.

Nitro + has a higher clock core, but there is no significant difference when compared to pulse. The Nitro card probably just came with really good VRAM.But for Cases Mining, I suggest buying Pulse.OC it, and you'll get the same effect as the Nitro+.

I think a better 6-8 GPU in your RIG. If you have a problem, you can easily detect and resolve it instead of the 20x GPU. Especially if in RIG there are different GPU series and brands because there are some cases that require different driver installation version even in same brand and series.

Yes affects the miner. when ETH fork, then there is 1 new coin from its fork. Whether the miner keeps mining the ETH from the assumption of Network hashrate diminishes due in part to miner switch mining to coins of ETH fork results. or also some people to move mining to new a coin with the assumption of his Network hashrate is still small.

Start with how much your budget. Buy a motherboard that has more 3 PCIe slots. Usually, the miner will buy a motherboard that has at least 6 PCIe slots. If you want MB to have more 7 Slots, you can buy MB that has an M2 adapter. For SSDs buying 128 GB or 256 GB, some people recommend the "Samsung" brand. PSU adjust to how much you will buy a video card (GPU). For GPU series you can choose AMD card or NVIDIA series. and don't forget you buy USB Riser.

example:
MB : Asrock H110 Pro BTC+ (13 slots), Asus Prime Z270-A (7 slots),Asrock H81 PRO BTC R2.0 (6 slots).
PSU : EVGA, Corsair etc.
GPU : AMD Cards (RX480,RX580, Vega), NVIDIA (1070,1070ti, 1080,1080ti)

If one Fan (Reference) "blower" removes heat from the back, away from the other components. The disadvantages are cooling and fan volume which is noisy. If Dual Fans is almost silent and performs much better. The downside is they throw all the heat into and potentially affect the heat of other components. You will then need a case of high airflow to avoid heat on the chassis. It's the best way to add outdoor equipment that can help cool or reach normal temperatures.

For Driver Crimson blockchain series Driver. If you try modded, What are the type memory your GPUs?.Use GPU-Z to determine the brand of memory. If you have Samsung/Elpida memory, you will want to copy the 1:1750 to 1:2000 OR. Those will get you much better rates than just copying 1750 down. For Hynix only has a different optimum setting for strap, clock, and voltage.

Yes, Worked.
PCIe 2.0 came out in 2007. It can handle 1–5 billion transfers per second. Each lane can send 500 MB/second. PCIe 3.0 came out in 2010. It can handle up to 8 billion transfers per second. The slot is the same, and the newer specification supports faster transfers, but is compatible with previous speeds.PCI express 2.0 has a peak speed of 8 GB/s. and PCIe 3.0 has a peak speed of 16 GB/s. No it does not influence the memory tech you have (DDR2/GDDR5/whatever)..
Speed is the main difference.

if you're using window, you only need to active window defender it's enough to protect your RIG.

I have the same experience with this motherboard and this is what I have done and it works:
1. Reset BIOS via jumper
2. Unplug the CMOS battery and plug it in again.
3. Move the CPU Memory Slot to DIM1 or DIM 2

Good luck

because here forum mining altcoins. I assume that you're mining using GPU. the definition of safe is very broad, whether safe is referred to hardware or commonly called RIG, or safe with the intent here about profitable.

(Build RIG) Start by selecting the motherboard, SSD, PSU, and GPU. if you're confused about choosing the above part, you can take a moment to read the thread in this forum about how to choose the good motherboard, SSD, and PSU. many threads that recommend about GPU that is tailored to your budget.

Try :
1. Move to other PCIE slot.
2. Check or Change your USB Riser.
3. Check Power from/ to USB Riser.
4. Check Software Driver.
5. Check your Windows.

good luck

POW to be POS is the normal situations. when your coins from POW to be POS still profitable if your coins rising the price. and when you still want that's coins, you can hold the coin and sell when high prices but this is high risk. But if you want change mining to other coins you can do it. most importantly you have knowledge about which coins are most profitable. in Altcoins a lot of coins that can be mined which of course based on calculations, which coin is profitable for the mine.

For 6/8 x GPU, you can get motherboard Asrock H81 PRO BTC R2.0 LGA 1150 (6xGPU), Asus Prime Z270-A (7xGPU+M2 adapter for 8x GPU), B250 BTC D8P (8xGPU).

For GPU, if you want AMD cards can buy Vega or Rx 580. If NVIDIA can buy 1070 ti. And SSD buys Samsung 128 GB or 256 GB. For PSU accordingly with GPU will you buy because every card has Power Consumption is different.

1060 has a TDP of 120 Watt if the math count is 4x120 = 480 Watt. Power required 480 Watts. To be more secure buy 750 W or 850 W, to keep the other parts so as not to lack power. it's good to buy a voltmeter tool like kill a watt meter.

Technically NiceHash only good on auto switching but our hashing power will drop. we can't see a difference between powerful and less power hashing cards. will be a difference standalone mining gateway software such as claymore etc. we can improve hashing power and power consumptions through GPU controller software.

the other thing about mining profit, if we're mining specific coins didn't mean we could hold it until the price rising. we can choose major coins with good prices and sell it instantly.

I don't understand what's meant by Lenovo PC. But for the motherboard, I'll explain in a nutshell. Ex: Asrock H81 PRO BTC R2.0 LGA 1150. For Processor can use i7 / i5 / Xeon / Pentium / Celeron (most importantly its Socket Intel LGA 1150). For mining is enough to use Celeron to reduce spending.

If talking motherboards for mining, some people are looking at PCIe slots that will be used for GPU. For the above motherboards it has: 1 x PCIe 2.0 x16, 5 x PCIe 2.0 x1. Which means it can be used for 6 xGPU