 📣📣📣 Hi everyone!EHF Advisor, prof. Arnold Mitnitsky answers questions about aging, frailty index, longevity, mathematical models that help to understand and fight against aging. Take a look at the 3rd part of his comments. 7. What does eHealth First mean for me?
Our work with eHealth First is in the very beginning. The way I am thinking about health and its measurement, its use in health care, is quite similar to what eHealth First is planning to do (see the White Paper for details). I am happy that my expertise in mathematical modeling and data analysis of complex biomedical systems gives me additional opportunities to push forward the agenda of understanding and thus improving health of individuals that ultimately will affect the quality of life of people in the world. I appreciate eHealth First for giving such opportunities. 8. What would we do, if many people live much longer than now?
Of course, aging of the populations presents some serious challenges to the healthcare systems all over the World. Such challenges are well known –increasing load on the health care is one of them. There are several scenarios that might happen if people live longer under discussion. Briefly, I think, most likely people will mature later than now, and keep changing slower than now. I see that the stretching the time scale of life is rather likely. People will go to retirement later than now, will have more productive life. In other words, the pace of aging will slow down. This will lead to the life extension and to the health span extension. I also believe that the society will find the way of mitigating any possible negative consequences of the life extension. In this I way, my view is rather optimistic. |
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  Hi everyone! CEO Николай Крючков выступил с презентацией о проекте eHealth First на Invest Battle Forum в Москве [на русском языке]
CEO Nickolay Kryuchkov made the presentation about eHealth First on the Invest Battle Forum [in Russian]
Find out more! https://youtu.be/8w7NQZiPOno |
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 Dear all!We know you are asking a lot of questions in this BT thread. Pls see our latest newsletter dd September 5, 2018 - this is about what happened during this summer: http://news.ehfirst.io/5sep2018
More news are coming. Thank you!
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 Hi everyone! EHF Advisor, prof. Arnold Mitnitsky answers questions about aging, frailty index, longevity, mathematical models that help to understand and fight against aging. Take a look at the 2nd part of his comments. 4. How aging could be measured?
Aging could be measured in many ways at the different levels. Our approach is to sum up multiple health attributes of the various nature (for simplicity, they should be dichotomized). The fraction of health deficits from the total number of health attributes (known as a frailty index or FI) is associated with multiple adverse outcomes (mortality, length or stay in hospital, morbidities). Thus, the FI is a useful (and holistic) utility measure that represents the state of health of the entire organism. There are several other measures that are in some use although not as widespread as the FI. One such measure is the DNA Methylation age that is based on the characteristics of epigenetic system. The other measures of the rate of aging, i.e. the different indices of biological age based on the batteries of biomarkers (e.g., obtained from the blood tests). The comparison of these measures has yet to be done in order to understand the advantages and limitation of each of them. 5. What about Frailty Index?
The frailty index (FI) is a measure of health of individuals (health utility) based on the accumulation of deficit approach. The FI is the ratio of health deficits present in an individual to the total number of deficits available in the database or in the study. The FI lies between 0 (no deficits present) to 1 (all deficits present) although empirical limit of the FI is close to 0.7 – the higher values of FI are incompatible with life. The frailty index is a robust predictor of adverse outcomes, such as mortality, and increasingly used in many epidemiological and clinical studies. The term includes “frailty” to reflect the vulnerability to stresses during the aging process, and “index” reflects the degree of such vulnerability. The FI should not be confused with the Frailty Phenotype which is a simple tool constructed from 5 characteristics of physical functioning although less comprehensive and less powerful than the FI. The FI is a measure of the global damage of the organism, it is not only empirically validated in multiple settings but also has a strong theoretical support in the new complex dynamical network model of aging and frailty developed by our group. 6. Why math models could help us fighting aging?
Mathematical modeling become increasingly popular in many areas of science and technology. There is a strong needs for that. In general, mathematical modeling is a central part of the theoretical advances in science. As people say: “Nothing is more practical than a good theory” (Kurt Lewin). As for controlling /postponing/ slowing aging (that I would prefer to “fighting aging”, “combating aging”, and such) the mathematical model is the only thing that allows to understand the processes under investigation, especially the processes involved the complex interactions and nonlinearities, like aging. Without modeling, what we have instead would be a bunch of semantical statements without the possibility to be tested (or falsified). If we do understand the aging process we can do something to modify it. Otherwise, we will be drown in the deep and murky waters of complexity and to fight with each other, instead of fighting aging (as often goes and goes on). |
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 Hi everyone! EHF Advisor, prof. Arnold Mitnitsky answers questions about aging, frailty index, longevity, mathematical models that help to understand and fight against aging. Take a look at the first part of his comments. 1. Briefly about myself and why I’m a Team member at eHealth First?My expertise and research interests lie in the area of mathematical modeling of complex biomedical systems. More specifically, I have a longstanding interests in modeling the process of aging. Being affiliated with the Dalhousie University (Department of Medicine) in Halifax, Canada, I was a recipient of several grants from the Canadian Institutes of Health Research to find the answer to the following questions: “How can we quantify aging in individuals and population?” How can we understand the biological aging and what is Biological age as a measure of the aging process, and finally how can we assess it? The problem of data integration is the crucial one in this respect, as more data becomes available with the explosion of the new technologies, such as genomics, proteomics, metabolomics, and advanced computational techniques, including the Artificial Intelligence (AI). The eHealth First team members have similar expirations and relevant expertise, so I was delighted to joint this team in the development of the approaches to assess health of individuals during aging with the hope that the new approaches will be implemented in practice. 2. What is aging?Aging is many things (aging is complex and has many aspects) and that is why people who study aging cannot agree all time (rather often). Aging can be defined at the different levels (cellular, subcellular, organ, entire organism). For me, it is a systemic nature of aging that is most important. We can say that aging is the process of changes in multiple aspects of health, declines in functional capacity, and functional reserve, increasing vulnerability to stresses, increasing the level of frailty. My focus is not about semantics but about developing the means that allow to quantify aging. Mathematical modeling lies in the heart of my approach. From that standpoint, we (with my colleagues, geriatrician, professor Kenneth Rockwood) suggested to assess aging as the process of accumulation of health deficits that can be found in multiple databases (clinical, epidemiological, etc.) and we have introduced a measure that can be readily applied to many data to make use of the information available currently and expected in the near future. 3. Why we age?The opinions about that greatly diverge. There are two major theories of aging: the damage accumulation, and genetic programming of aging. I am in favor of the accumulation of damage approach to the origin of aging, as a cause of aging and that is well supported by our mathematical models, especially the network model of aging that shows how the propagation of damage occurs in complex networks. The accumulation and propagation of damage in complex dynamical networks (that represent our organism) explains the major quantitative characteristics of the aging processes, including the exponential increase of mortality with age (the celebrated Gompertz law of mortality) and the accumulation of health deficits with age that ultimately results in increasing the risks of death. |
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Dear all! We are glad to inform you, EHF Company signs the $1M Investment Agreement with Indian entrepreneur and investor Mr. Mehta (Lilavaty Hospital). http://www.lilavatihospital.com |
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  In June 28, EHF Representatives met with CEO and co-founder of GHC and Kamegaya Companies (Japan) Masanobu Kamegaya san. The Memurundum of Understanding was signed. http://www.kamegaya.co.jp |
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  Hi everyone! India has great opportunities in the development of health system, and eHealth FIrst Project can contribute to this. So EHF Team is looking for Indian partners and investors. EHF Representatives met with Indian businessman and investor Mr. Sethi (Mumbai, India). |
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    Hi everyone! On June 29 EHF Representatives met with Senior Representatives of SOGO Medical Co., Ltd. in Tokyo, Japan and discussed potential collaboration in development and inplementation of EHF IT Platform. SOGO Medical is a company operated in a medical, heatlhcare and pharmaceutical areas in Japan and globally. https://www.sogo-medical.co.jp/english/co_information.php |
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  Hi everyone! Today in Tokyo EHF representatives including CEO Nickolay Kryuchkov meet with Director of International Medical Care at the International University of Health and Welfare Dr. Takuya Ogawa. The collaboration in the IT Platform development and its implementation in Japan were discussed. The International University of Health and Welfare (IUHW) was founded in 1995 as the first comprehensive university of health and welfare in Japan, with the objective of developing health and welfare specialists and raising their status. Now it’s a university with around 8,300 students in 10 schools and 24 departments, as well as a graduate school, across 6 campuses, located in Ohtawara City in Tochigi Prefecture, Narita City in Chiba Prefecture, Minato City in Tokyo, Odawara City in Kanagawa Prefecture, and Fukuoka City and Okawa City in Fukuoka Prefecture. The University has its own hospitals in Japan. |
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having a mvp before ico(as you mentioned) will be very helpful. Although that too many months until december but hopefully we will catch the train in december like last december.
But as far as i can see, interest in this thread decreased in these days. i should add that.
Pre-ICO will be in September and maybe even earlier. Now we are focusing on big and mid-sized crypto and fiat investors. Also we are re-launching our community management. Stay with us. Thank you!  |
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The website's layout and designs are nice, the details are good, I like the ANN thread composition. I just hope that all your plans will come true and you fulfill all your missions and visions.
Thanks a lot!  |
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  CEO Nickolay Kryuchkov visits Seoul (June 20-21) and Tokyo (June 23-30).
Plan an appointment!
eHealth First is interested in investments and strategic partnerships! CEO Nickolay Kryuchkov visits Seoul in June 20-21, 2018, and Tokyo in June 23-30, 2018. To arrange a meeting, please write to nkryuchkov@ehfirst.io or Telegram @nkryuchkov1, or Skype nkryuchkov. See you soon! |
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Tell me please, what is the price of the token now and to what time will ICO continue? According to the white paper start of the ICO begins in June-July 2018, but on the site is written Pre-ICO September 2018.
Hi! The Pre-ICO dates will be determined later. Now we planned to establish it in September 2018. And yes, the ICO, Round 1, will be launched in November-December 2018. Pls see the presentations here https://www.ehfirst.io/#wpMore translations to come soon. The presentation in English: https://drive.google.com/file/d/1bg4VTrOJqIXUsbUTPK7WEUxxGggJdqkR/viewClear. Then it might be better to change the information in the road map. I understand correctly that you want to show the MVP at the Pre-ICO or do you also postpone the deadlines? Hi, We are going to show the MVP before the launch of ICO, Round 1 (this December). This could be changed depends on financing. The development has started. |
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I see that at the current moment about 183,000 tokens of 100,000,000 available are distributed / sold. Another month will go Pre-ICO. It's strange even why the project attracted so few investors.
Yep, we have 83 applications to the Whitelist. Nevertheless, our focus for now is early-stage investors and community management re-launch. |
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Tell me please, what is the price of the token now and to what time will ICO continue? According to the white paper start of the ICO begins in June-July 2018, but on the site is written Pre-ICO September 2018.
Hi! The Pre-ICO dates will be determined later. Now we planned to establish it in September 2018. And yes, the ICO, Round 1, will be launched in November-December 2018. Pls see the presentations here https://www.ehfirst.io/#wpMore translations to come soon. The presentation in English: https://drive.google.com/file/d/1bg4VTrOJqIXUsbUTPK7WEUxxGggJdqkR/view |
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