Are you trying to operate cgminer and guiminer at the same time? Only one will work at a time.

For guiminer to work, make sure your username/password and host and port are set exactly as listed. If you miss a space or something it will not work. Also, try creating another worker.

I don't know what you are running for hardware, but I would go checkout a bitcoin calculator to see if it is even worth your time trying to mine.