Andy I'm new to this game too; started last month. I have fifteen RX580's and a dozen GTX1060's (only eight of those in-service). I use SmOS (simplemining.net operating system) and mine ETH exclusively with Nanopool. The "real world" numbers are basically this: I am making more money per day than WhatToMine.com says I should be making. I attribute that to Nanapool's setup and my GPU's processing more shares than WhatToMine can estimate. For example, WhatToMine is estimating like $3.67/hr yet I just looked at my proceeds overnight (ETH price has been stable), and over the last 13 hours my mining proceeds have netted me $4.29/hr. That is a 14% difference from estimate to reality. $88/day versus $103/day.
What's your thoughts on the GTX 1060's vs your RX 580's? Was there a reason you went for two different cards?