I'll add my name to the list of people of who have been happy with Coinbase.
I had to wait out the transaction times, but since there really aren't many options in the US, I'm not complaining.

Yes, their prices suck. Yes, if your a newb and want to signup and buy bitcoins RIGHT NOW, you're going to have to wait.

However, for me, they have been upfront about their policies, and have lived up to what they said they would do. YMMV

Coinbase seems to be about the only the only one I have been able to use a US account to buy and sell bitcoins on (and they are not cheap).

I haven't had any problems with BTC-e when it comes to depositing, trading, and withdrawing coins.  I use them frequently to trade between currencies, without issue.  Though, I would agree others that you shouldn't keep any high balances in your wallet there.  Not just for problems with their "flexible" acceptable use policy, but also just for security reasons.