Simple version: No.

More complex version: Coins don't move.  A tx simply transfers "ownership".  So either the tx is included in the blockchain and the receiver "owns" them or it never does and the sender still owns them.

The only possibility of coins being lost would be an error where it was sent to a wrong address.  Even then someone will get the coins.  It is possible to send coins to an address which exists but for which nobody has the private key.  The odds of making a typo that does that are ~1 in 4 billion.