As has already been mentioned, it's vital that you know how Bitcoin and any other cryptocurrencies you are interested in work. If you're looking to invest and make profit it's also important that you try to learn how the markets work and how to read charts. You don't need to be an expert but having an idea of when to buy or sell is always a great thing to have.
Most importantly though I'd say is making sure your security is super tight. Make sure that every decide you use to access any wallets or exchanges is safe to use and always make sure you back up your wallets and private keys, but never share them. Cold storage is your best bet for this or using a hardware wallet like a Ledger.
Above all else though, make sure you enjoy it and have an interest in it