I assume Ledger support already got you to check "browser support"? (On you Ledger... plug it in to power it up, enter PIN, select the Litecoin app... select "settings"... select "browser support"... select "No".)
Also, is your ledger being registered by Windows? Do you get the "USB connected" sounds when you enter your PIN and unlock the Ledger?
I got my Nano s two days ago direct from Ledger/France. This process is driving me nuts.
Chrome browser is running on Linux Mint 18.1, desktop PC
I upgraded to Firmware v1.4.1
I assigned the PIN
I downloaded LTC from the Ledger Manager extension
I scrolled to LTC on the Ledger
I double-clicked on LTC
It says "Use Wallet to View Accounts" with a right down arrow
I clicked on the down arrow, it now says "about" with a right down arrow
I clicked on the down arrow and it says "quit app" (no settings nor browser support option)
I deleted LTC from the Ledger Manager and started the above process again with no luck. Should I try this in Win10? I'd rather not screw around with Linux code unless it's a simple procedure.
Edited to Add: Problem solved. I was missing the LTC ledger app in my files. I noticed on here and at Reddit the term "Litecoin Ledger Wallet" and mistook that for the Ledger Manager. What can I say, I'm a noob with the Ledger. Was able to transfer a small test amount from Coin Base to the Ledger wallet with no problem.