Like it says in the Readme.txt you can use a command line start.bat file or the config.txt configuration file to set the miner options.

So basically it should look like something like this ?

setx GPU_FORCE_64BIT_PTR 0
setx GPU_MAX_HEAP_SIZE 100
setx GPU_USE_SYNC_OBJECTS 1
setx GPU_MAX_ALLOC_PERCENT 100
setx GPU_SINGLE_ALLOC_PERCENT 100
EthDcrMiner64.exe -epool ssl://asia1.ethermine.org:5555 -ewal 0x6559Bc27401361e82705677eB62C73e4fD93384a.RigKir -epsw x

If just want to mine ETH set the miner to -mode 1 in the config or .bat file, then set the pool, wallet address or worker as explained in the Readme.txt. Most pools have a 'getting started' help page with the string to add for the pool's Stratum address and port to use. For failover pools, in case the main pool goes down, add pools to the epools.txt file.

Almost all miners trigger antivirus and it's generally a false postive due to miners being used to mine on other people's computers without their consent. You can disable your antivirus before downloading a miner and create an exclusion for the folder where you keep your miners.