extra bittrex feature - orders now  not accepted !!

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LIMIT SELL
You are selling 600 units of ISR at .0005 BTC each.

With 0.00007500 commission, your order total is 0.2992500 BTC
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or at least it would have been, if our system actually worked.
please hold while the value of your coins plummets.

its an interesting puzzle
using a blockchain one can verify that a given block comes before a second, and if the second is timestamped
e.g. using a timestamp server
then the second definitely came before something that comes after time t...which tells you nothing about the timing

The valid folds are required to be local minima of the folding energy landscape.
These are easy to check (taking O(K) cycles in a K-dimensional landscape) but hard to find (taking something like O(A^K) cycles).

ya its a good point, consider otoh that the blockchain notion came from the 'timestamp server' which is just that which proves that a given operation was performed after time t, while what  would be needed is a way to prove that a given operation was performed before  time t

I have been trying to come up with an alternative proof of work allowing arbitrary calculations to be performed instead of hashing.

I blv I have a way to combine blockchain protection with e.g. folding (or any other difficult operation)
In case of proteins, based on a large library of proteins to be folded, in case of any other calculation a (large) library of such calculations.

The idea employs a blockchain just as btc except that the hash of
(transactions in the current block+hash of previous block)
is used to choose a problem from the library.  The lowest energy solution (for proteins, or best/only solution for other problems) is sought.
Whoever comes up with lowest local minimum within 10-minute block time gets block reward.

(solution + transactions + hash of previous block)
are hashed together for the next block a-la bitcoin.  Faking a block is now similarly difficult.
A bit more detail here http://telavivmakers.org/index.php/Protein_coin - including way to allow users to design algorithms yet prevent best coder/folder from gaining control.