Thank you for your answer.
I don't found how to run the prune mode.

Regarding:
"If you insist to keep all blockchain data, then move blockchain to external storage or add/replace with new HDD to your Mac are the only option.
Just move whole bitcoin folder to different location, make sure there's no bitcoin folder on default location and run Bitcoin Core again. Bitcoin Core think it's first time you run Bitcoin Core and ask you to choose directory location, then you just need to choose location of moved bitcoin folder."

I don't really know how to do; could you detail me the way to do it please?

HELP

I downloaded Bitcoin core in my Mac, i have 251Go HD memory.
It took almost all the space but it's worked.
I received and sent BTC few times.
When Bitcoin core start to synchronize last week and suddenly told me that i don't have enough space.
It's arrived to 78%progress, i erase almost all the documents and programs in my computer to free space but it's not enough.
What can i do???