Hi, do you use one of the GPU card to display your monitor?
If yes you should use internal video output on mainboard to your monitor.
Also do you use your computer only for mining?
Did you setup extra virtual memory? Eg you should have atleast 16GB virtual memory
If you have free mainboard slots you can try to move the GPU that mine at a low rate to another slot.
Maybe also upgrade you OS a new Win10 install may run better, it is best if you have another HD that you can swap with a new OS