I think the next "Block Reward Halving", estimated for mid 2016, will have a significant impact on mining. If all mining operations just ignore it, their income will just get cut in half one day in Mid-2016. Since the larger operations usually have to liquidate some portion of their mined Bitcoins to pay for rent, electricity, salaries and the like, what's leftover will be reduced significantly. I would also venture to say that absent a corresponding increase in the price of Bitcoin, the value of the mining hardware will also drop in a big way, since each bit hardware doesn't produce as much per unit of time. Since I have zero idea what drives the price of Bitcoin, beyond the usual supply/demand theories, there isn't anything to pressure the price upwards. That ill crush many mining operations. I've said before, I can't think of any other industrial operation where this happens "overnight" like it will with Bitcoin.
no one would know what is going to happen. if the price is high enough and ASICs become efficient enough, most mining operators would ignore it as long as it still brings in profit after deducting expenses.