Apart from the aforementioned software limitations , you'll run to the problem of having not enough power. How much of a psu and motherboard do you expect to e able to run 8 full fledged gpus?
When not using a case, it's not so difficult to use multiple PSUs, and with PCI-e extender cables with molex connector, this seems fairly doable, since the power won't go through the motherboard. Or am I wrong in this?