you only need to backup again if you have new addresses, wallet is only keys to your addresses.
balances for those addresses are on the blockchain.

if you use the coin control feature when you send coin, then you can specify a change address for the unspent portion.
this way you know the change can go to an address that is already backed up.

have more than one backup.

How to make FLOZ address in vanitygen

vanitygen -X 35 PATTERN

haters can suck

FAtdicKs2QLTZZVhCxWwfQRaNnGpKDMbsg

yes