Disclaimer: I've mined all the coins I have on a GPU in the past ten months.
All those people holding thousands of bitcoins, hoping to become the next Jobs/Gates/Buffett: make sure you don't smother what is happening right now. Use your head. You are *not* Jobs/Gates/Buffett...you got lucky. Take some profits and let other people profit from the rise.
Seriously, think about it.
Peace!
How is holding their coins smothering what is happening? If the price is $100/BTC or $1000/BTC it doesn't make a difference it just means something is 1BTC or 0.1BTC to purchase. The only thing that will cause an issue with using bitcoin is day trading causing massive fluctuations in the price as businesses are likely to adjust their prices (most places selling goods/services for BTC are unlikely to pay their suppliers in BTC so the exchange rate matters).
Someone not selling their coins now is no different to someone formatting their HDD and losing their wallet, the coins aren't in circulation so supply is reduced and the value goes up. When they sell supply will increase and price goes down.
If I had thousands I probably would have sold off a heap to pay off my mortgage but each to their own.