Basically, the idea is that you sell your bitcoins on an exchange, and then transfer the money to your bank from there. There's quite a multitude of ways to do this.
You do not have to back it up every time you make a new transaction, because all of the transactions are stored in the blockchain. If you add a new address to your wallet then you should back it up, because the private key for that address won't be in the earlier backups that you made.
So: if you add a new bitcoin address to your wallet, you need to back it up. New transaction, no.
Download a miner and start mining, and it will become more clear how it works. I don't think SLI makes any difference - just as long as the miner can use all of the cards.