Well you have given me some hope this isn't a catastrophe.....  I am re-synching again, with pruning off.  It takes a while but no big deal.

Thank you for the response.  I am new to this..... so I don't have the in-depth experience to troubleshoot. 

Have a great day!

I am hoping for a little assistance trying to recover my BTC wallet.  I am using BitCoin Core v0.20.1.

I initially installed the entire blockchain, and pruned.  I created a single wallet and funded it via an online exchange, and the funds appeared in my wallet within a short time.  A that time I was done with what I wanted to do.  I shut down BTC Core.  Skip ahead a couple of weeks and my GF wanted a wallet of her own.  So I started up Core, re-synched what it needed and made her wallet.  We repeated the same process I had done, and everything worked ok. 

The problem is now, I cannot go back and open my first wallet.  The exact error is:

"Wallet loading failed:  Prune: last wallet synchronization goes beyond pruned data.  You need to -reindex (download the whole blockchain again in case of pruned node)."

So last night I ran core using the -reindex switch, and let it completely download the blockchain again.  This morning I tried to open my first wallet, and same problem.  Wallet loading failed.

I don't know what to do at this point.  Should I -reindex one more time, and turn pruning off?  I'm open to any and all suggestions.  It's not a million dollars, but it still feels like a loss, and I'm in desperate need of a "win"
 these days.

Here's hoping someone has some further suggestions. 

Thanks everyone.  Stay safe.  Stay warm (it's -30 here)