Is there any possible way they could successfully "break" bitcoin or the blockchain with so many users now? (Besides a 51% attack)
If there is ever a quantum shift in processing power (like 20 orders of magnitude) then weird things could happen. If I was to write the sci-fi thriller detailing the death of bitcoin it would start with a student coming up with some radically different new way to do computation, then eventually using that computation power to reduce the amount of time required to crack ECDSA from a billion years, to 5. Then he/she spends the rest of her graduate carrier cracking the signature for the largest UTXO on the blockchain.
The moment people realized that someone had successfully performed a brute force ECDSA attack,
BTC becomes worthless.
There will come a time.... many eons from now, when ECDSA is not as hard to crack as it is in this century. When that day comes, all the UTXOs that are locked with ECDSA will need to be swiped to stronger lock. May be centuries away, but for those that feel
BTC will replace fiat, this is day that needs to be accounted for.