If they lose the keys for their wallets even that is private keys or backup phrases like the usual wallets right now then it is not possible anymore to recover those amounts of money and it will be lost forever and the only thing that the person can do is to be careful in securing their accounts next time so they will not be worry about losing the keys for the wallet.
For bitcoin users, the key is the only thing to secure their money. Bitcoin has high security, so if you lose the key, you have no way to retrieve it.