Well the only way a virus could steal money from you / your wallet, is going to be if you're not safe online and something infects your computer. This is also saying that you don't have a competent antivirus that was able to hit this virus before it infected your computer. So you can use your coins and your wallet whereever and with whatever you want, I'd just make sure that your computer is safe.
If you don't think it is, use a fresh computer / wipe the computer. Or use a mobile device to store your coins and send from, much harder to hack this sort of device.
thank you. I use a hardware wallet for the majority of my holdings. so my concern is really when I plug in my hardware wallet, is there some possible way that a virus software could transfer coins from my hardware wallet? or is there not much to worry about there?
I don't think any virus/malware can transfer coins from hardware wallet without your permission, you have to press a physical button to confirm an outgoing transaction.
although some virus/malware can be tricky and replace bitcoin address in your clipboard, just verify the BTC address you're sending to on your device's screen. other than that, you don't really have to worry about anything.