DONT USE CROSSFIRE, it loses mhash, about 10 per card. Use extenders from your X1 PCI-E/PCI to x16 PCI-E. Use phatK kernel with ATI CARDS (5 and 6 series). I use 4 5850's and the first GPU as to be clocked down to 975 instead of 1000 for some reason as when all 4 cards are active, it starts to bomb the mhash above 975/300 clock. Very strange but think it might be a common thing maybe?
And GUI miner, Get rid. Pheonix seems to be the best for mhash but diablo is by far the easiest and if you install the 10.4 drivers (which include stream 2.1) then its not a lot to call between them. If you use phoenix, make sure all instacies run on 1 affinity (1 core) on your CPU as theres a bug that makes it 100% your cpu with 2 or more instances of it going. Causes the comp to run really slow, although the mhash doesnt seem to be affested