The release notes for 0.15 seem to explain it:
https://bitcoin.org/en/release/v0.15.0.1#multi-wallet-support2nd paragraph explains how to use multiple wallets:
Multi-wallet is enabled by using more than one -wallet argument when starting Bitcoin, either on the command line or in the Bitcoin config file.
Then to access a specific wallet, check the 3rd bullet point down regarding changes to RPC interface:
When running Bitcoin Core with multi-wallet, wallet-level RPC methods must specify the wallet for which they’re intended in every request. HTTP RPC requests should be send to the <RPC IP address>:<RPC port>/wallet/<wallet name>/ endpoint, for example: 127.0.0.1:8332/wallet/wallet1.dat/. bitcoin-cli commands should be run with a -rpcwallet option, for example: bitcoin-cli -rpcwallet=wallet1.dat getbalance.