I had the same issue with my rig at the beginning. These settings solved the issue:
1500 / 1035 is the combination that works on most 280x with tc 8192 also update your driver.
this always gives results above 700kh/s
-I 13 -g 2 -w 256 --thread-concurrency 8192 --gpu-engine 1035 --gpu-memclock 1500 --auto-fan --temp-cutoff 95 --temp-overheat 75 --auto-gpu
but make sure you've got the latest amd driver and if it's a beta driver try the one before that.
Read my first post to find similarities, I am also using Toxcis. Rig has been running stable since.