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[nc50lc]

You've reinstalled Core so the issue must be in the data directory.
There are couple of issues that could cause, "Error opening Block database" but since you have just disabled pruning,
it won't hurt to start with a clean blocks directory to sync from scratch. It will sync from start after disabling pruning anyways.

Find Bitcoin's data directory, the default is: C:\Users\Drake\AppData\Roaming\Bitcoin (Shortcut: WinKey+R | Enter %appdata% | open "Bitcoin" folder)
I've included your username since it's already in the logs.
Create a backup of that folder (for safety) and delete "blocks", "chainstate" and "index" folders inside the original.
While you're at it, double-check the bitcoin.conf file (open with txt editor) if you still have any pruning settings enabled, all must be disabled.

Run Bitcoin core and it should sync from start (see if pruning is still ticked in the GUI).