Looks like it's going to be easier to set up HWI than I thought, seeing that there are binary releases on it on Github for Linux/MacOS/Windows:
https://github.com/bitcoin-core/HWI/releases/tag/2.0.2This seems more or less a way to loosely integrate HWI rather than a framework since there aren't any other signers that I know of which can interface with hardware wallets.
For Windows, I'd prefer a signer built with C++ since python tends to be... tacky at installing dependencies when you run it for the first time. Plus making people install Python to run a signer & Bitcoin core makes the setup complicated for new users and C++ compiled with MSVC/Xcode can simply be distributed as one installer or binary.
I don't see any of that happening at HWI but given that it's reviewed as well as Bitcoin Core, it's possible that an alternative signer project be made that does distribute these binaries with a similar amount of review.