I think Coinbase and Kraken are good exchanges, but I left both Coinbase and Kraken a long time ago, so I can not suggest you use those exchanges. I suggest you use Binance, Hotbit, FTX, Bittrex, KuCoin (you can select only one if you want). I often use Binance and KuCoin but I do not use them for daily trading as I trade only if I think the market moves good. All of the exchanges I mention is allow you to withdraw big funds but of course, you need to verify your account. Bittrex needs a Passport to verify while the other exchanges can use your local identity.
I would prefer to use and suggest Binance, FTX and Kucoin. Amongst these three exchanges, I like the UI of Binance and Kucoin that are convenient to use.
I don't like the UI of FTX but if you are finding an exchanges with potential good growth, FTX is good and FTT is the FTX token that is cool for your investment too.
Hotbit was hacked months ago and even their security was improved, you must be careful a bit. Obviously, Binance was hacked years ago but no more in last two years. I mean we need more time to see how Hotbit security is improved and how secured it is now.
Bittrex has bad reputation because of their KYC policy and implementation years ago. This bad policy and implementation caused to their lost leading position to Binance.