Opening or managing a casino is always lucrative. I don't think a crypto collapse will have much of an impact on that. People are always gambling. You do have to have a certain policy if people play in a certain currency, if it goes the other way, like a sharp increase, then I wouldn't cash out all BTC and other crypto to your bank account. You can then become a thief of your own wallet because the price for players has suddenly become a lot more favorable. A crash is always short-lived, as we have seen in the past. There will always be a time of recovery for the crypto, and that will also encourage players to gamble more. Players aren't as likely to worry about temporary crashes when gambling.
As we have seen, people gamble no matter what the market situation is.
BTC price goes up and down, and yet, people still gamble their money.
They may reduce their spending habits, but they will always play.
This is why, casinos and other gambling sites survived during the pandemic period and other crises.
Offline casinos may be closed, but online casinos will always be open 24/7 without interruption.
It now depends on the casino owners how they will tackle different scenarios and offer rewards or bonus in every bottleneck they will encounter with.