Probably the easiest text in the html to replace in the page per-user is:
title="View the profile of ldrgn"
In forum threads, that is the description for the user name link - when you hover over the poster's user name, it shows that text. The greasemonkey script you can make for each user to replace this with your own text:
document.body.innerHTML= document.body.innerHTML.replace(/title=\"View the profile of ldrgn\"/g,"title=\"ldrgn is a cool dood for a noob\"");
document.body.innerHTML= document.body.innerHTML.replace(/title=\"View the profile of deepceleron\"/g,"title=\"deepceleron helped me with Greasemonkey\"");
Now when you hover over our user names, it shows this description instead.