I am surprised Deprived did not touch on this, as it was a comment he made just a bit ago that has had me thinking about the mostly nonexistant bid depth at BitFunder:
Bitfunder doesn't allow leveraging same funds across orders on multiple securities in the same wat LTC-Global/BTC.CO do - so unfortunately we have to keep more capital there to maintain same volume of orders. Because of that I have to pass up marginally profitable trades - but there's enough decent opportunities there to still make trading there worthwhile.