Not too sure what you mean?
Any graphics card will fit in the PCI-E x16 slot.
You didn't mention your PSU which is IMO the most important component and the answer to your question is highly dependent on that.
Either way the answer is up to you, there are a plethora of threads on this forum about what card to get and the difference between them especially for equihash.
To spoon feed you as you wish :
https://zdeveloper.org/wiki:zcash_mining_benchmarksThe above link has most speeds and wattage, however, the costing and ROI calc is up to you
edit - your HDD's & processor cooler have no relevance