Actually adjusted for stales BTC is the most profitable coin to mine right now, ASICs or GPUs. I'm not counting megacoin.
Megacoin 106.67%
Bitcoin 100.00%
Novacoin 99.14%
PPCoin 95.65%
Feathercoin 93.25%
BitBar 90.27%
Right now a $2000 investment in BTC mining generates a whopping $180 per month with Block Erupters or $123 with GPUs. Expect this to fall drastically momentarily.
Bitcoin Difficulty
15,605,633
Next difficulty (estimate): 19,302,748
In short order mining will become an exercise of punching the gas on gravel, if it's not already.