These entries should always be altered when creating an altcoin otherwise there could be cross-talk with other currencies using similar code. It's best to do it right at the very start, before the genesis hash is created and the coin is released otherwise you will have a major fork to deal with.
One way to do it is to go to an online hexadecimal converter and use it to produce random characters for the end of your pchMessage 0x?? strings. Think up four random numbers between 0 and 255 and convert them from decimal to hex i.e. 177 = b1, 223 = df.
Change the last part of your 0x?? strings to your new values and make sure it's done for the main network in main.cpp.
Thanks for your great answer.