I personally think that having a 50 fold increase in unlikely in the next 4 years, especially when you consider that even the biggest bull market that was seen so far in the bitcoin scene last year only resulted in a 2000% gain over a year. It's quite absurd to think that in 2022, markets will be that bullish again.
That's not to say that I'm not bullish over the long term. In fact, I believe that it would only be a matter of time before BTC does hit $250k. But it will take a lot more people adotping the currency, and it will take fiat depreciation to some degree. So 2022 seems a bit too early for me, at least.
It really depends what the adoption curve looks like. Take a look at some others from recent history:
Now, what would you put % adoption at? Under 5%? Definitely under 10% I think. Let's assume that Bitcoin follows a similar curve as most other ubiquitous technologies. If you combine that with a supply that is mostly mined out already, I think the potential explosion to 6-7 figures could happen extremely fast.
It's impossible to predict beforehand, and I am personally prepared for a long and painful bear market right now. However, my experience from 2014-2016 tells me many of us (yes, even the believers) will be in utter disbelief when that move finally happens.