Make sure there isn't something that triggers the PSU's Over Current Protection (OCP), or a short circuit.
Also, could be something wrong with your mains power. Do you have an UPS? Do you have a voltmeter that can measure up to 250V AC?
When you power on, what precisely do you have connected? Just motherboard, CPU, RAM? Or a Radeon too, some usb adapter, HD, etc...
You may have screwed up something with dual-PSU, two different kinds of risers, and some connection error