How safe are desktop wallets ?

[Crypto-cabbie]

As I am fairly new to the Altcoin scene I am learning as I go along.

I have recently installed a couple of wallets on my desktop on which I have enabled Staking.

I just wondered how safe it is to leave these wallets staking in the background, obviously as they increase in value over time, the risk of loss becomes bigger.

Is there any precautions I should be taking on top of the wallet encryption.

Any suggestions gratefully received.