When I do this it lets me change the clocks but when I hit apply it goes back to zero. Not sure why. Can anyone help. Thanks.
Here's the section you need to change in the MSIAfterburner.cfg file:
EnableUnofficialOverclocking = 1
UnofficialOverclockingEULA = I confirm that I am aware of unofficial overclocking limitations and fully understand that MSI will not provide me any support on it
UnofficialOverclockingMode = 2
AccessibilityCheckingPeriod = 0
Just to make sure I am understanding you correctly, after you edit, save and close the file and then open up afterburner again it is changing the file back? If you are keeping the AB program open while you are editing the file it would likely change it back. Make sure you close AB, edit the file from an Administrator acct and then close and save it before running AB again.
If that does not do it try using a different app to OC with. Like Trixx; https://www.sapphireselectclub.com/ssc/TriXX/TriXX.aspx