ProofofConceptDev (OP)
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August 23, 2018, 01:30:53 PM Last edit: August 23, 2018, 02:04:33 PM by ProofofConceptDev |
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I am also to explain PoC token to you and may I be crowdfund from you.
PoC is ERC20 token
Proof of concept Token
Proof of concept (PoC) is a realization of a certain method or idea in order to demonstrate its feasibility, or a demonstration in principle with the aim of verifying that some concept or theory has practical potential. A proof of concept is usually small and may or may not be complete.
Usage history
The appearance of the term in news archives suggests it might have been in common use as early as 1967. In 1969 Committee on Science and Astronautics. Subcommittee on Advanced Research and Technology hearing proof of concept was defined as following "The Board defined proof of concept as a phase in development in which experimental hardware is constructed and tested to explore and demonstrate the feasibility of a new concept".
One of the early definitions of the term "proof of concept" was by Bruce Carsten in the context of a "proof-of-concept prototype" in the column "Carsten's Corner":
Proof-of-Concept Prototype is a term that (I believe) I coined in 1984. It was used to designate a circuit constructed along lines similar to an engineering prototype, but one in which the intent was only to demonstrate the feasibility of a new circuit and/or a fabrication technique, and was not intended to be an early version of a production design.
The column also provided definitions for the related but distinct terms 'breadboard', 'prototype', 'engineering prototype', and 'brassboard'. Examples
Filmmaking
Sky Captain and the World of Tomorrow, 300, and Sin City were all shot in front of a greenscreen with almost all backgrounds and props computer-generated. All three used proof-of-concept short films. In the case of Sin City, the short film became the prologue of the final film.
Pixar sometimes creates short animated films that use a difficult or untested technique. Their short film Geri's Game used techniques for animation of cloth and of human facial expressions later used in Toy Story 2. Similarly, Pixar created several short films as proofs of concept for new techniques for water motion, sea anemone tentacles, and a slowly appearing whale in preparation for the production of Finding Nemo. Engineering
In engineering and technology, a rough prototype of a new idea is often constructed as a "proof of concept". For example, a working concept of an electrical device may be constructed using a breadboard. A patent application often requires a demonstration of functionality prior to being filed. Some universities have proof of concept centers to "fill the 'funding gap'" for "seed-stage investing" and "accelerate the commercialization of university innovations". Proof of concept centers provide "seed funding to novel, early stage research that most often would not be funded by any other conventional source".
Business development
In the field of business development and sales, a vendor may allow a prospect customer to trial a product. This use of proof-of-concept helps to establish viability, to isolate technical issues, and to suggest overall direction, as well as providing feedback for budgeting and other forms of internal decision-making processes.
In these cases, the proof of concept may mean the use of specialized sales engineers to ensure that the vendor makes a best-possible effort.
Security
In both computer security and encryption, proof of concept refers to a demonstration that in principle shows how a system may be protected or compromised, without the necessity of building a complete working vehicle for that purpose. Winzapper was a proof of concept which possessed the bare minimum of capabilities needed to selectively remove an item from the Windows Security Log, but it was not optimized in any way. Software development
In software development, the term proof of concept often characterises several distinct processes with different objectives and participant roles: vendor business roles may utilise a proof of concept to establish whether a system satisfies some aspect of the purpose it was designed for. Once a vendor is satisfied, a prototype is developed which is then used to seek funding or to demonstrate to prospective customers.
A steel thread is technical proof of concept that touches all of the technologies in a solution. By contrast, a proof of technology aims to determine the solution to some technical problem (such as how two systems might integrate) or to demonstrate that a given configuration can achieve a certain throughput. No business users need be involved in a proof of technology. A pilot project refers to an initial roll-out of a system into production, targeting a limited scope of the intended final solution. The scope may be limited by the number of users who can access the system, the business processes affected, the business partners involved, or other restrictions as appropriate to the domain. The purpose of a pilot project is to test, often in a production environment.
Drug development
Although not suggested by natural language, and in contrast to usage in other areas, Proof of Principle and Proof of Concept are not synonymous in drug development. A third term, Proof of Mechanism, is closely related and is also described here. All of these terms lack rigorous definitions and exact usage varies between authors, between institutions and over time. The descriptions given below are intended to be informative and practically useful.
The underlying principle is related to the use of biomarkers as surrogate endpoints in early clinical trials. See for example the introductory discussion on pages 3 to 9 of Downing's Biomarkers and surrogate endpoints: clinical research and applications. In early development it is not practical to directly measure that a drug is effective in treating the desired disease, and a surrogate endpoint is used to guide whether or not it is appropriate to proceed with further testing. For example, although it cannot be determined early that a new antibiotic cures patients with pneumonia, early indicators would include that the drug is effective in killing bacteria in laboratory tests, or that it reduces temperature in infected patients - such a drug would merit further testing to determine the appropriate dose and duration of treatment. A new antihypertension drug could be shown to reduce blood pressure, indicating that it would be useful to conduct more extensive testing of long-term treatment in the expectation of showing reductions in stroke (cerebrovascular accident) or heart attack (myocardial infarction). Surrogate endpoints are often based on laboratory blood tests or imaging investigations like X-ray or CT scan.
Proof of Mechanism or PoM relates to the earliest stages of drug development, often pre-clinical (i.e., before trialling the drug on humans, or before trialling with research animals). It could be based on showing that the drug interacts with the intended molecular receptor or enzyme, and/or affects cell biochemistry in the desired manner and direction.
Proof of Principle or PoP relates to early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of the condition. Early stage clinical trials may aim to demonstrate Proof of Mechanism, or Proof of Principle, or both.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped.
Proof of Concept PoC refers to early clinical drug development, conventionally divided into Phase I and Phase IIa.
Phase I is typically conducted with 10 to 20 healthy volunteers who are given single doses or short courses of treatment (e.g., up to 2 weeks). Studies in this phase aim to show that the new drug has some of the desired clinical activity (e.g., that an experimental anti-hypertensive drug actually has some effect on reducing blood pressure), that it can be tolerated when given to humans, and to give guidance as to dose levels that are worthy of further study. Other Phase I studies aim to investigate how the new drug is absorbed, distributed, metabolised and excreted (so-called ADME studies).
Phase IIa is typically conducted in up to 100 patients with the disease of interest. Studies in this Phase aim to show that the new drug has a useful amount of the desired clinical activity (e.g., that an experimental antihypertensive drug reduces blood pressure by a useful amount), that it can be tolerated when given to humans in the longer term, and to investigate which dose levels might be most suitable for eventual marketing.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped. If the drug continues, it will progress into later stage clinical studies, termed "Phase IIb" and "Phase III".
Phase III studies involve larger numbers of patients treated at doses and durations representative of marketed use, and in randomised comparison to placebo and/or existing active drugs. They aim to show convincing, statistically significant evidence of efficacy and to give a better assessment of safety than is possible in smaller, short term studies.
A decision is made at this point as to whether the drug is effective and safe, and if so an application is made to regulatory authorities (such as the US Food and Drug Administration [FDA] and the European Medicines Agency) for the drug to receive permission to be marketed for use outside of clinical trials.
Clinical trials can continue after marketing authorisation has been received, for example to better delineate safety, to determine appropriate use alongside other drugs or to investigate additional uses.
See also how PoC Token works with everything here
3D printing Case study Concept car Example: Wikibooks-poc Feasibility study Prototype Sanity testing Tech demo Technology readiness level Trinity (nuclear test)
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zayachkivska
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August 23, 2018, 01:56:43 PM |
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so your project has a unique concept, very few projects with this type, because in my opinion this concept is new, so I want to see further developments. and great steps to be taken every week
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ProofofConceptDev (OP)
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August 23, 2018, 02:07:53 PM |
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PoC is of interest to people because it has requirement of evidence, typically deriving from an experiment or pilot project, which demonstrates that a design concept, business proposal, etc. is feasible.
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Jezzy of Jensen
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August 23, 2018, 04:37:14 PM Last edit: August 29, 2018, 07:10:36 PM by Jezzy of Jensen |
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Hello Dev, I am interested in your project, it sounds unique and one of a kind. A proof of concept is a demonstration, the purpose of which is to verify that certain concepts or theories have the potential for real-world application. POC is therefore a prototype that is designed to determine feasibility, and after that, the next stage is deliverables. There are so many real-world application possibilities. ![](https://ip.bitcointalk.org/?u=https%3A%2F%2Fcdn.pbrd.co%2Fimages%2FHBsjpZ4.png&t=665&c=g8EphBsN2Hwaow)
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Jezzy
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Jezzy of Jensen
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August 23, 2018, 04:42:39 PM |
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Please keep me informed of the project development and I hope to hear good things to come.
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Jezzy
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ProofofConceptDev (OP)
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August 23, 2018, 04:56:43 PM |
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Thank you. The goal of our project is to determine our main demographic and establish market viability with our target audience. To achieve this, we will leverage the partner, iResearch. This market intelligence technology firm delivers intuitive online tools for insight-driven decision-making.
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TheCheek
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August 23, 2018, 11:07:43 PM |
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Thank you. The goal of our project is to determine our main demographic and establish market viability with our target audience. To achieve this, we will leverage the partner, iResearch. This market intelligence technology firm delivers intuitive online tools for insight-driven decision-making. Great new and innovative project, and this solves challenges faced by other projects in crypto that can now use an emerging PoC platform as an online tool to test their business ideas. There’s a huge risk attached to every new business. We’re talking the loss of lots of money. That’s why it is important to test a business idea before scaling up the business. Simply prove a business idea works and is commercially viable, and projects are off to a great start. I have sent you a PM, Dev, I am interested in participating with your project team.
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ProofofConceptDev (OP)
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August 24, 2018, 12:06:31 AM |
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Thank you. The goal of our project is to determine our main demographic and establish market viability with our target audience. To achieve this, we will leverage the partner, iResearch. This market intelligence technology firm delivers intuitive online tools for insight-driven decision-making. Great new and innovative project, and this solves challenges faced by other projects in crypto that can now use an emerging PoC platform as an online tool to test their business ideas. There’s a huge risk attached to every new business. We’re talking the loss of lots of money. That’s why it is important to test a business idea before scaling up the business. Simply prove a business idea works and is commercially viable, and projects are off to a great start. I have sent you a PM, Dev, I am interested in participating with your project team. Thank you for your kind words and PM (I have replied). PoC is looking for a Campaign Manager so do not hesitate to send us your CV.
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ProofofConceptDev (OP)
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August 24, 2018, 12:48:25 AM |
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PoC has already received an offer of a listing at TokenJar.IO, and this is even before PoC has been released.
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Jezzy of Jensen
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August 24, 2018, 04:35:56 PM |
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PoC has already received an offer of a listing at TokenJar.IO, and this is even before PoC has been released. This is wonderful news to be offered a listing when most projects have to look for one and then pay. TokenJar must know a good project when it sees one. Perhaps when the project is live PoC could be listed on HitBTC, as I am sure the exchange would offer a heavy discount. I also think YoBit exchange is very good especially since traders get Yotra for all their trade fees. Effectively, given Yotra's trading price is about 1 BTC, there are 0 trading fees. This is very good to promote more trade, and there will be more holders of PoC.
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Jezzy
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Krezz2017
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August 24, 2018, 05:28:10 PM |
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What is the project like? What is the proof of the concept? Provide white paper and team information. And that is too much text and it is not clear what meaning you put.
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BennyBenny
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August 24, 2018, 06:04:33 PM |
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I am also to explain PoC token to you and may I be crowdfund from you.
PoC is ERC20 token
Proof of concept Token
Proof of concept (PoC) is a realization of a certain method or idea in order to demonstrate its feasibility, or a demonstration in principle with the aim of verifying that some concept or theory has practical potential. A proof of concept is usually small and may or may not be complete.
Usage history
The appearance of the term in news archives suggests it might have been in common use as early as 1967. In 1969 Committee on Science and Astronautics. Subcommittee on Advanced Research and Technology hearing proof of concept was defined as following "The Board defined proof of concept as a phase in development in which experimental hardware is constructed and tested to explore and demonstrate the feasibility of a new concept".
One of the early definitions of the term "proof of concept" was by Bruce Carsten in the context of a "proof-of-concept prototype" in the column "Carsten's Corner":
Proof-of-Concept Prototype is a term that (I believe) I coined in 1984. It was used to designate a circuit constructed along lines similar to an engineering prototype, but one in which the intent was only to demonstrate the feasibility of a new circuit and/or a fabrication technique, and was not intended to be an early version of a production design.
The column also provided definitions for the related but distinct terms 'breadboard', 'prototype', 'engineering prototype', and 'brassboard'. Examples
Filmmaking
Sky Captain and the World of Tomorrow, 300, and Sin City were all shot in front of a greenscreen with almost all backgrounds and props computer-generated. All three used proof-of-concept short films. In the case of Sin City, the short film became the prologue of the final film.
Pixar sometimes creates short animated films that use a difficult or untested technique. Their short film Geri's Game used techniques for animation of cloth and of human facial expressions later used in Toy Story 2. Similarly, Pixar created several short films as proofs of concept for new techniques for water motion, sea anemone tentacles, and a slowly appearing whale in preparation for the production of Finding Nemo. Engineering
In engineering and technology, a rough prototype of a new idea is often constructed as a "proof of concept". For example, a working concept of an electrical device may be constructed using a breadboard. A patent application often requires a demonstration of functionality prior to being filed. Some universities have proof of concept centers to "fill the 'funding gap'" for "seed-stage investing" and "accelerate the commercialization of university innovations". Proof of concept centers provide "seed funding to novel, early stage research that most often would not be funded by any other conventional source".
Business development
In the field of business development and sales, a vendor may allow a prospect customer to trial a product. This use of proof-of-concept helps to establish viability, to isolate technical issues, and to suggest overall direction, as well as providing feedback for budgeting and other forms of internal decision-making processes.
In these cases, the proof of concept may mean the use of specialized sales engineers to ensure that the vendor makes a best-possible effort.
Security
In both computer security and encryption, proof of concept refers to a demonstration that in principle shows how a system may be protected or compromised, without the necessity of building a complete working vehicle for that purpose. Winzapper was a proof of concept which possessed the bare minimum of capabilities needed to selectively remove an item from the Windows Security Log, but it was not optimized in any way. Software development
In software development, the term proof of concept often characterises several distinct processes with different objectives and participant roles: vendor business roles may utilise a proof of concept to establish whether a system satisfies some aspect of the purpose it was designed for. Once a vendor is satisfied, a prototype is developed which is then used to seek funding or to demonstrate to prospective customers.
A steel thread is technical proof of concept that touches all of the technologies in a solution. By contrast, a proof of technology aims to determine the solution to some technical problem (such as how two systems might integrate) or to demonstrate that a given configuration can achieve a certain throughput. No business users need be involved in a proof of technology. A pilot project refers to an initial roll-out of a system into production, targeting a limited scope of the intended final solution. The scope may be limited by the number of users who can access the system, the business processes affected, the business partners involved, or other restrictions as appropriate to the domain. The purpose of a pilot project is to test, often in a production environment.
Drug development
Although not suggested by natural language, and in contrast to usage in other areas, Proof of Principle and Proof of Concept are not synonymous in drug development. A third term, Proof of Mechanism, is closely related and is also described here. All of these terms lack rigorous definitions and exact usage varies between authors, between institutions and over time. The descriptions given below are intended to be informative and practically useful.
The underlying principle is related to the use of biomarkers as surrogate endpoints in early clinical trials. See for example the introductory discussion on pages 3 to 9 of Downing's Biomarkers and surrogate endpoints: clinical research and applications. In early development it is not practical to directly measure that a drug is effective in treating the desired disease, and a surrogate endpoint is used to guide whether or not it is appropriate to proceed with further testing. For example, although it cannot be determined early that a new antibiotic cures patients with pneumonia, early indicators would include that the drug is effective in killing bacteria in laboratory tests, or that it reduces temperature in infected patients - such a drug would merit further testing to determine the appropriate dose and duration of treatment. A new antihypertension drug could be shown to reduce blood pressure, indicating that it would be useful to conduct more extensive testing of long-term treatment in the expectation of showing reductions in stroke (cerebrovascular accident) or heart attack (myocardial infarction). Surrogate endpoints are often based on laboratory blood tests or imaging investigations like X-ray or CT scan.
Proof of Mechanism or PoM relates to the earliest stages of drug development, often pre-clinical (i.e., before trialling the drug on humans, or before trialling with research animals). It could be based on showing that the drug interacts with the intended molecular receptor or enzyme, and/or affects cell biochemistry in the desired manner and direction.
Proof of Principle or PoP relates to early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of the condition. Early stage clinical trials may aim to demonstrate Proof of Mechanism, or Proof of Principle, or both.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped.
Proof of Concept PoC refers to early clinical drug development, conventionally divided into Phase I and Phase IIa.
Phase I is typically conducted with 10 to 20 healthy volunteers who are given single doses or short courses of treatment (e.g., up to 2 weeks). Studies in this phase aim to show that the new drug has some of the desired clinical activity (e.g., that an experimental anti-hypertensive drug actually has some effect on reducing blood pressure), that it can be tolerated when given to humans, and to give guidance as to dose levels that are worthy of further study. Other Phase I studies aim to investigate how the new drug is absorbed, distributed, metabolised and excreted (so-called ADME studies).
Phase IIa is typically conducted in up to 100 patients with the disease of interest. Studies in this Phase aim to show that the new drug has a useful amount of the desired clinical activity (e.g., that an experimental antihypertensive drug reduces blood pressure by a useful amount), that it can be tolerated when given to humans in the longer term, and to investigate which dose levels might be most suitable for eventual marketing.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped. If the drug continues, it will progress into later stage clinical studies, termed "Phase IIb" and "Phase III".
Phase III studies involve larger numbers of patients treated at doses and durations representative of marketed use, and in randomised comparison to placebo and/or existing active drugs. They aim to show convincing, statistically significant evidence of efficacy and to give a better assessment of safety than is possible in smaller, short term studies.
A decision is made at this point as to whether the drug is effective and safe, and if so an application is made to regulatory authorities (such as the US Food and Drug Administration [FDA] and the European Medicines Agency) for the drug to receive permission to be marketed for use outside of clinical trials.
Clinical trials can continue after marketing authorisation has been received, for example to better delineate safety, to determine appropriate use alongside other drugs or to investigate additional uses.
See also how PoC Token works with everything here
3D printing Case study Concept car Example: Wikibooks-poc Feasibility study Prototype Sanity testing Tech demo Technology readiness level Trinity (nuclear test)
Hello, I would like to remark that I find your project idea intellectually stimulating on a number of levels. The idea of a platform for PoC is a first in crypto at the level you are doing it. Well done. In my opinion, the PoC method allows sharing internal knowledge among the team, explore emerging technologies, and provide an evidence of concept to the client for their product. First, the developer assigned to the POC conducts research and begins to develop the feature with the goal of proving that it’s feasible. Once this is proven, the PoC is extended to develop an integrated working model to provide a snippet of the final product. After that it’s either presented to the client and the product team to sell the idea for an upcoming project or it can be used internally within the development teams to share knowledge and stimulate innovation. In essence, the platform will integrate technology and user experience to create a product (or multiple products).
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BennyBenny
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August 24, 2018, 06:10:53 PM |
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Thank you. The goal of our project is to determine our main demographic and establish market viability with our target audience. To achieve this, we will leverage the partner, iResearch. This market intelligence technology firm delivers intuitive online tools for insight-driven decision-making. Indeed, that you a partnered by iResearch is a demonstration that your project should be taken extremely seriously.
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ProofofConceptDev (OP)
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August 25, 2018, 01:27:48 AM |
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I am also to explain PoC token to you and may I be crowdfund from you.
PoC is ERC20 token
Proof of concept Token
Proof of concept (PoC) is a realization of a certain method or idea in order to demonstrate its feasibility, or a demonstration in principle with the aim of verifying that some concept or theory has practical potential. A proof of concept is usually small and may or may not be complete.
Usage history
The appearance of the term in news archives suggests it might have been in common use as early as 1967. In 1969 Committee on Science and Astronautics. Subcommittee on Advanced Research and Technology hearing proof of concept was defined as following "The Board defined proof of concept as a phase in development in which experimental hardware is constructed and tested to explore and demonstrate the feasibility of a new concept".
One of the early definitions of the term "proof of concept" was by Bruce Carsten in the context of a "proof-of-concept prototype" in the column "Carsten's Corner":
Proof-of-Concept Prototype is a term that (I believe) I coined in 1984. It was used to designate a circuit constructed along lines similar to an engineering prototype, but one in which the intent was only to demonstrate the feasibility of a new circuit and/or a fabrication technique, and was not intended to be an early version of a production design.
The column also provided definitions for the related but distinct terms 'breadboard', 'prototype', 'engineering prototype', and 'brassboard'. Examples
Filmmaking
Sky Captain and the World of Tomorrow, 300, and Sin City were all shot in front of a greenscreen with almost all backgrounds and props computer-generated. All three used proof-of-concept short films. In the case of Sin City, the short film became the prologue of the final film.
Pixar sometimes creates short animated films that use a difficult or untested technique. Their short film Geri's Game used techniques for animation of cloth and of human facial expressions later used in Toy Story 2. Similarly, Pixar created several short films as proofs of concept for new techniques for water motion, sea anemone tentacles, and a slowly appearing whale in preparation for the production of Finding Nemo. Engineering
In engineering and technology, a rough prototype of a new idea is often constructed as a "proof of concept". For example, a working concept of an electrical device may be constructed using a breadboard. A patent application often requires a demonstration of functionality prior to being filed. Some universities have proof of concept centers to "fill the 'funding gap'" for "seed-stage investing" and "accelerate the commercialization of university innovations". Proof of concept centers provide "seed funding to novel, early stage research that most often would not be funded by any other conventional source".
Business development
In the field of business development and sales, a vendor may allow a prospect customer to trial a product. This use of proof-of-concept helps to establish viability, to isolate technical issues, and to suggest overall direction, as well as providing feedback for budgeting and other forms of internal decision-making processes.
In these cases, the proof of concept may mean the use of specialized sales engineers to ensure that the vendor makes a best-possible effort.
Security
In both computer security and encryption, proof of concept refers to a demonstration that in principle shows how a system may be protected or compromised, without the necessity of building a complete working vehicle for that purpose. Winzapper was a proof of concept which possessed the bare minimum of capabilities needed to selectively remove an item from the Windows Security Log, but it was not optimized in any way. Software development
In software development, the term proof of concept often characterises several distinct processes with different objectives and participant roles: vendor business roles may utilise a proof of concept to establish whether a system satisfies some aspect of the purpose it was designed for. Once a vendor is satisfied, a prototype is developed which is then used to seek funding or to demonstrate to prospective customers.
A steel thread is technical proof of concept that touches all of the technologies in a solution. By contrast, a proof of technology aims to determine the solution to some technical problem (such as how two systems might integrate) or to demonstrate that a given configuration can achieve a certain throughput. No business users need be involved in a proof of technology. A pilot project refers to an initial roll-out of a system into production, targeting a limited scope of the intended final solution. The scope may be limited by the number of users who can access the system, the business processes affected, the business partners involved, or other restrictions as appropriate to the domain. The purpose of a pilot project is to test, often in a production environment.
Drug development
Although not suggested by natural language, and in contrast to usage in other areas, Proof of Principle and Proof of Concept are not synonymous in drug development. A third term, Proof of Mechanism, is closely related and is also described here. All of these terms lack rigorous definitions and exact usage varies between authors, between institutions and over time. The descriptions given below are intended to be informative and practically useful.
The underlying principle is related to the use of biomarkers as surrogate endpoints in early clinical trials. See for example the introductory discussion on pages 3 to 9 of Downing's Biomarkers and surrogate endpoints: clinical research and applications. In early development it is not practical to directly measure that a drug is effective in treating the desired disease, and a surrogate endpoint is used to guide whether or not it is appropriate to proceed with further testing. For example, although it cannot be determined early that a new antibiotic cures patients with pneumonia, early indicators would include that the drug is effective in killing bacteria in laboratory tests, or that it reduces temperature in infected patients - such a drug would merit further testing to determine the appropriate dose and duration of treatment. A new antihypertension drug could be shown to reduce blood pressure, indicating that it would be useful to conduct more extensive testing of long-term treatment in the expectation of showing reductions in stroke (cerebrovascular accident) or heart attack (myocardial infarction). Surrogate endpoints are often based on laboratory blood tests or imaging investigations like X-ray or CT scan.
Proof of Mechanism or PoM relates to the earliest stages of drug development, often pre-clinical (i.e., before trialling the drug on humans, or before trialling with research animals). It could be based on showing that the drug interacts with the intended molecular receptor or enzyme, and/or affects cell biochemistry in the desired manner and direction.
Proof of Principle or PoP relates to early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of the condition. Early stage clinical trials may aim to demonstrate Proof of Mechanism, or Proof of Principle, or both.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped.
Proof of Concept PoC refers to early clinical drug development, conventionally divided into Phase I and Phase IIa.
Phase I is typically conducted with 10 to 20 healthy volunteers who are given single doses or short courses of treatment (e.g., up to 2 weeks). Studies in this phase aim to show that the new drug has some of the desired clinical activity (e.g., that an experimental anti-hypertensive drug actually has some effect on reducing blood pressure), that it can be tolerated when given to humans, and to give guidance as to dose levels that are worthy of further study. Other Phase I studies aim to investigate how the new drug is absorbed, distributed, metabolised and excreted (so-called ADME studies).
Phase IIa is typically conducted in up to 100 patients with the disease of interest. Studies in this Phase aim to show that the new drug has a useful amount of the desired clinical activity (e.g., that an experimental antihypertensive drug reduces blood pressure by a useful amount), that it can be tolerated when given to humans in the longer term, and to investigate which dose levels might be most suitable for eventual marketing.
A decision is made at this point as to whether to progress the drug into later development, or if it should be dropped. If the drug continues, it will progress into later stage clinical studies, termed "Phase IIb" and "Phase III".
Phase III studies involve larger numbers of patients treated at doses and durations representative of marketed use, and in randomised comparison to placebo and/or existing active drugs. They aim to show convincing, statistically significant evidence of efficacy and to give a better assessment of safety than is possible in smaller, short term studies.
A decision is made at this point as to whether the drug is effective and safe, and if so an application is made to regulatory authorities (such as the US Food and Drug Administration [FDA] and the European Medicines Agency) for the drug to receive permission to be marketed for use outside of clinical trials.
Clinical trials can continue after marketing authorisation has been received, for example to better delineate safety, to determine appropriate use alongside other drugs or to investigate additional uses.
See also how PoC Token works with everything here
3D printing Case study Concept car Example: Wikibooks-poc Feasibility study Prototype Sanity testing Tech demo Technology readiness level Trinity (nuclear test)
Hello, I would like to remark that I find your project idea intellectually stimulating on a number of levels. The idea of a platform for PoC is a first in crypto at the level you are doing it. Well done. In my opinion, the PoC method allows sharing internal knowledge among the team, explore emerging technologies, and provide an evidence of concept to the client for their product. First, the developer assigned to the POC conducts research and begins to develop the feature with the goal of proving that it’s feasible. Once this is proven, the PoC is extended to develop an integrated working model to provide a snippet of the final product. After that it’s either presented to the client and the product team to sell the idea for an upcoming project or it can be used internally within the development teams to share knowledge and stimulate innovation. In essence, the platform will integrate technology and user experience to create a product (or multiple products). Developing a proof of concept can help a product owner to identify potential technical and logistical issues that might interfere with success. It also provides the opportunity for an organization to solicit internal feedback about a promising product or service, while reducing unnecessary risk and exposure and providing the opportunity for stakeholders to assess design choices early on in the development cycle. .
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leetrongway
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August 25, 2018, 06:54:31 AM |
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Good afternoon. What’s the nominal price of the token at the current sales stage?
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Jezzy of Jensen
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August 25, 2018, 03:46:08 PM |
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In anticipation of the PoC platform I have done some research with regard to PoC to share data which may be very useful to the PoC team. This uses the Fintech Proof-of-Concept. The Bank of England (BoE), Britain’s Central Bank, published a Proof-of-Concept (PoC) which analyzes the possibilities of allowing users to share data in a safe and secure network. The bank partnered with blockchain infrastructure provider, Chain, to examine the problem and work on the possible solutions. While the PoC was not implemented practically, both companies tried to answer questions that arose from developing a distributed network system. For instance, allowing participants from all over the world to share a blockchain network raises privacy concerns. In such cases, even with the use of cryptography, people may find ways to access transactions of other users. The Bank of England took a central authority and a regulator as an example. If they were exchanging data and transferring assets, transactions would have to be concealed from other participants. Additionally, it would have to be ensured that people in the “consensus process [do] not have full visibility of transaction details.” Using encryption techniques doesn’t guarantee complete security from attackers. One way to avoid it would include creating a partially distributed network where data is only shared between those participants directly involved in each transaction. PDF
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Jezzy
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jacasta19
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August 25, 2018, 05:18:17 PM |
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Incredibly, this project provides a good start, I hope that the team does not lose the ability to promote the company in the future, this will provide good opportunities for investors.
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ProofofConceptDev (OP)
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August 25, 2018, 07:22:35 PM |
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Thank you to the kind messages, the PoC team is inspired by them. There are so many reasons to use PoC in many areas. One example is its use by Software Developers early on in the development cycle of a software or to sell the concept of the software. Validation of technical feasibility, identification of the possible expectations from a platform, identification of potential stumbling blocks and determination of the scope and customization level required necessarily to complete a project are some of the concepts of early development cycle of a software where PoC can be used. By tokenizing PoC, it allows for this process to be open and adjusted to necessary input of an emerging PoC platform.
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BennyBenny
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August 25, 2018, 08:59:19 PM |
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Thank you to the kind messages, the PoC team is inspired by them. There are so many reasons to use PoC in many areas. One example is its use by Software Developers early on in the development cycle of a software or to sell the concept of the software. Validation of technical feasibility, identification of the possible expectations from a platform, identification of potential stumbling blocks and determination of the scope and customization level required necessarily to complete a project are some of the concepts of early development cycle of a software where PoC can be used. By tokenizing PoC, it allows for this process to be open and adjusted to necessary input of an emerging PoC platform.
Software developers can also use PoC to identify performance issues of the project. These days most of the software developers assemble various applications and solutions by using the functions and services offered by other applications and using certain integration methods. These integration methods are used in the overall context of the software to test them with trial products. It also helps in validating the assumptions regarding the possibilities provided by the framework or platform. In this way the results provided by the use of Proof of Concept include the confidence factors of technical feasibility along with the factors influencing the overall estimate of the efforts as well as the scope of efforts.
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TheCheek
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August 25, 2018, 11:06:04 PM |
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Thank you to the kind messages, the PoC team is inspired by them. There are so many reasons to use PoC in many areas. One example is its use by Software Developers early on in the development cycle of a software or to sell the concept of the software. Validation of technical feasibility, identification of the possible expectations from a platform, identification of potential stumbling blocks and determination of the scope and customization level required necessarily to complete a project are some of the concepts of early development cycle of a software where PoC can be used. By tokenizing PoC, it allows for this process to be open and adjusted to necessary input of an emerging PoC platform.
Software developers can also use PoC to identify performance issues of the project. These days most of the software developers assemble various applications and solutions by using the functions and services offered by other applications and using certain integration methods. These integration methods are used in the overall context of the software to test them with trial products. It also helps in validating the assumptions regarding the possibilities provided by the framework or platform. In this way the results provided by the use of Proof of Concept include the confidence factors of technical feasibility along with the factors influencing the overall estimate of the efforts as well as the scope of efforts. I am very excited by this project, especially regarding the the blockchain proof of concept (PoC). Many are already investing heavily in a blockchain proof of concept and distributed ledger technology, exploring use cases for their own business operations and for customers (including B2B and consumer applications). A recent Gartner survey revealed that 66% of CIOs and IT leaders believe blockchain will create business disruption, and have established budgets to experiment with the the technology; 5% of those surveyed said they will spend more than $10 million on blockchain in the next 5-10 years. As a forward-looking technology and/or business leader, you are probably contemplating the potential for disruption in your industry — and maybe even wondering about how you can leverage blockchain to create a competitive advantage for your business. So, how do you cut through the noise and hyperbole around blockchain and decide where to start? The answer is simple: Invest in a blockchain proof of concept in 2018.
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