There are some badboy ASIC miners coming out from Q2 this year, check out Zeusminer and Excalibur... They will be OK for pure scrypt mining but you leave yourself open for changes in the algo, which GPU's can handle fairly easily...
I was recently worried about these and almost put an order in... Then I discovered algo's like Scrypt-Jane & Keccak and realised this is where the fun is at...
Sshhh...don't go around spreading things like that