MicroStrategy, Grayscale, square etc, it was a year when companies chose Bitcoin as their reserve asset, if you missed some of the big news, see Fillippone's thread Bitcoin treasuries to keep track of it. That being said I found a good article that seemed to suggest that Bitcoin is the best reserve asset we've got, mind you that I'm not agreeing 100% with the writer, but many of his claims seems to be true, so why not allow the community have their say on this, see this excerpt:
I personally consider this excerpt the best part of the article and something we all can apply as we make investment plans for the future, but that's Bitcoin v Fiat/traditional institutions on the subject, and I agree that fiat is vulnerable to inflation/devaluation and manipulation and Bitcoin is prolly a much better reserve asset than just leaving your funds lying in your bank account losing its value with every year. Since Bitcoin is a good hedge, it's the better option imo. But what about Bitcoin v Gold or Bitcoin v real estate investment etc, the article has something to say about that, see:
Do you think Bitcoin is the best reserve asset we have atm? Much better than Gold and others, and can we continually trust Bitcoins value to keep appreciating with the years.

The article: https://cointelegraph.com/news/bitcoin-is-the-best-treasury-reserve-asset-humanity-s-ever-had (it's much better you read the article first before commenting)

Obviously I trust in bitcoin however we cannot minimize the risks we are incurring by holding bitcoin, lets take some of the questions you ask as an example, will bitcoin still exist 100 years in the future? I think the answer to that is yes, but will it retain its value or even increase it after 100 years? This is something I do not know, what if during the next decades a new coin that is many times better than bitcoin appears and that is the coin that gets widely adopted by the world and not bitcoin?

And just as gold can be lost bitcoin can be lost just as easily, there are many horror stories about lost and broken hard drives, people that lost the piece of paper were they wrote their seed words or their paper wallets, all in all bitcoin is a great way to store your money but it is still subject to many of the same issues.

This is a big question actually. And I think this is what is stopping big companies to dive into Bitcoin. Companies generally look into utilites and cash flows of the asset they are buying and investing. Now when a company decides to buy cryptocurrency it's actually making a pretty ironic choice. Not because cryptocurrencies is a bad asset. But making it as your reserve asset is against the very utility of Bitcoin. If everyone starts using Bitcoin as an asset then it's nothing but just peanuts.
 
For example if there is a metal say "X"(Bitcoin) and it's used in certain process and is the only metal that can be used in the process(transaction) and this is the only use of this metal X.
Now this metal is scarce so a lot of people begin to hoard the complete supply of X. Now as the whole supply has been hoarded. The processors (people doing transactions in BTC) the would either use some other metal than this high value metal or maybe the group of Hoarders will release supply slowly to ensure price remains high. Now this market scenario is completely manipulative so at the end the users will try to find some alternatives.

This is the reason I think most of the companies would refrain from investing in Bitcoin as reserve currency.

We can't conclude that bitcoin will be the best nor the absolute reserve asset for like what you mentioned things change differently in time. We can't assume what will bitcoin be in the future as early as now though, bitcoins show good characteristics as an investment. But that will not be a guarantee since countries like China are aiming to create their own centralized digital currency which other countries around that globe are doing the same and as of the moment, they are not considering bitcoin as the best one that can resolve most of the issues we are experiencing in fiat.

Moreover, looking at bitcoin as the best reserve asset can also be true if any country like US will adopt it legally as their own currency.

There is no way bitcoin can be labeled the best reserve asset right now.  Not because I don't believe in bitcoin or crypto but because its still in its early infacy.  It just came about 10 years ago we can be placing as the industry financial standard yet at this point cmon.

Bitcoin is a dex crypto, CBDC's aren't going to affect it in any way since it's more or less centralized and keeping them as a reserve currency is the same as holding the country's fiat currency that's vulnerable to inflation/devaluation/manipulation. Mind you that we never expected the government to believe in Bitcoin, that's prolly why they are imposing regulations here and there and launching CBDC's, but Bitcoin is free from their third party control, so whether they 'consider' it or not, it's more of the 'people's' coin and it's value looks like it'll keep appreciating down the years.

The scarcity of reserve assets makes it valuable and there are more than 100 years for the last mined BTC. Maybe there will be supercomputers which can decypher the private keys or can be a threat against the blockchain technology. From this perspective, I doubt the governments will likely accept the BTC as a regular payment method let alone accepting it as a reserve currency. Gold, Euro, and CHF as the main reserve financial assets have a strong backup but this can be standard for government in order to exclude the BTC as a reserve currency.

I tend to agree with you.
This is technically speaking, if it is a reserve asset that the value will be sustainable then Bitcoin isn't the correct one for we all know that Bitcoins value changes from time to time and it doesn't guarantee that it can keep its price or value on a higher rate in time.

We can't even assume that Bitcoin will be in circulation in decades or centuries from now which we all hope to be but investing in Bitcoin and keep it for the future you might just end up desperate if one day your investment in Bitcoins will lose all its value and totally no worth anymore, (which is impossible but we can't mere this fact).

Yes, Bitcoin is the best if we rely on the previous 10 years of market data. The problem is no one knows what will happen in the next 10 years. The believer will believe the price will keep rising while the skeptics won't be so sure.

MicroStrategy et al. did a risky bet. They will win big if the price movement is still the same (as historical data). For me, I'll bet on Bitcoin directly, not these companies' stocks.

It can't be given that kind of recognition now because as you said , it is still very new. Gold has been there for long and tasted to stand the test of time. Even though I don't think gold is but bitcoin is not generally accepted yet like fiat is.