Access to Ledger Nano S (2018 version) without PIN and seed words?

[Pmalek]

Yes. I contacted them and got some hope

Their answer was:
Currently, there is no attack for the Ledger but we’re working on it.

I think that Joe mentioned in one of his videos that the STM32 microcontroller chips are flawed in design and vulnerable to attacks. It's just a matter of finding the correct way to attack them and having enough resources to finance the attack and the tools needed. And if I am not mistaken, both the Trezor and Ledger use this type of chip. Who knows, maybe they are working on something as we speak...

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[NeuroticFish]

And if I am not mistaken, both the Trezor and Ledger use this type of chip.

According to the HW lists with Secure chip, list updated in September 2022, Trezor still didn't seem to add secure chip to their devices.
And after the thing I've found in their blog (see my other post) I would not be surprised if they will not add secure element at all.

[Pmalek]

According to the HW lists with Secure chip, list updated in September 2022, Trezor still didn't seem to add secure chip to their devices.

They don't have a secure element chip, but they are still using a model of the STM32 microcontroller. And the same thing is true for Ledger assuming all the data in that table is correct. The STM32 models they use are different though.

And after the thing I've found in their blog (see my other post) I would not be surprised if they will not add secure element at all.

I wonder what they found, and if that information was shared with the chip manufacturers? Even though they are probably aware of their flaws, hence the non-disclosure agreements. Whatever it is, physical access to the device and the chip is surely mandatory. Maybe that or a similar research is the reason why Joe considers these chips as being flawed as well. 

[dkbit98]

Their answer was:
Currently, there is no attack for the Ledger but we’re working on it.

That is going to be interesting to see, he is certainly working on something new.
It's possible to hack almost anything if you have the right tools and skills, especially if you have the right insider information available.
My theory is that he could find a way to hack old ledger model S device, than ledger can say how they already retired this device and issue was already fixed in model X and S plus 
There is higher chance for older chips to get hacked, but he needs to think outside the box to perform this attack with success.