To use as a controller for a USB stick or pod - sure. To actually 'plug' an ASIC into - no because the chip needs supporting circuitry and connections to work that a PC does not have.
do you mean the circuitry wouldn't be able to handle the wattage the ASIC uses, or do you there is literally nowhere the plug the ASIC into?
If the latter, is there no way to modify the circuit boards to be able to install an ASIC?
Not trying to be difficult here, mostly just thinking out load