Interesting videos I watched them both. Creator of the video is worried about transhumanism which is reasonable and probably why he added the disturbing imagery pictures of hell, video of a man cutting up a monkey brain, the images of the poor cat and monkey who got their brains operated on while they were alive etc.
Essentially the videos lay out the reasons homo sapiens are in danger of extinction caused by our own achievements. Overall it is a solid presentation. It makes a strong case that our fate whatever its outcome is entirely beyond our abilities to alter. Further progress is inevitable. Our very essence will relentlessly push us farther down our current path.
The best quote comes at the end of the second video.
We may be on the threshold of acquiring godlike capacities... we may reach towards a kind of omniscience we may reach towards a kind of omnipotence... but technology is never going to be able to transform us into divinely loving merciful or compassionate beings. That part the moral dimension... remains a problem remains a choice and in that sense (transhumanism) does not change human history
Transhumanism as described would radically change everything we know, and yet on a fundamental level it would change nothing.