I think everyone is saying to themselves "this is a very complex topic and you are just asking to get hacked and lose all of your coins if you aren't completely on-point with your security procedures". Or, maybe that was just what I was thinking.
I'd try some basic research first by searching these forums. Then, if you have more specific questions, come back with those.
Here's a free link to get you started that helped me quite a bit:
http://bitcoin.stackexchange.com/questions/18402/what-is-the-safest-method-managing-a-large-number-of-receiving-bitcoin-addresses