As smart as Karpeles is, he highly overestimated his own ability. I dont think he did anything criminal (gross negligence is a slippery slope - so maybe) but his failure to acknowledge his own incompetence and responsibility in this matter is disheartening.
If he just came out and said, "hey, my bad" I could at least respect that a little bit. He says hes disappointed no reporter ever asks him "How are YOU doing?"
Nobody cares about you Mark, because you just wont take responsibility for a disaster which you allowed to occur through your incompetence.
Playing the victim is easy. Taking responsibility is hard, and because hes never done that, I cant ever respect him.
I don't think taking responsibility is smart from a legal prospective. From what I can tell, it is not known when exactly the bitcoin was stolen from gox. As a result anyone who were to sue who is responsible could argue that all of the bitcoin was stolen at the time they collapsed (almost certainly not true - I would say that the majority of the lost coins were likely from when bitcoin was trading at very little).
If he were to come out and admit that it was his fault that the bitcoin was stolen/missing then he could potentially be held personally responsible for the missing bitcoin.