Read an article once, author claimed up to 30% coins are lost forever.
Anyone can claim any amount of coins have been lost; absent coins being burned to a verifiable burn address, there's no way to prove any loss.
Yes, if someone comes along saying they lost 5 BTC, I will fee horrible for them, but even if the sum of coins reported lost by people to things like crashed hard drives, etc was 2 million, in my mind, I wouldn't think that the remaining coins should be any more valuable, because there is no way to prove those coins lost, rather than people trying to manipulate perceived prices.
People come up with all sorts of theories about when to say that coins have been lost; if they haven't moved for X amount of time, presumed lost, etc... That doesn't make sense.
First off, early miners could have simply backed up their wallets and haven't felt the need to combine all of their coins at a new address, and a lot of people claim to have created paper wallets and done things like burying them somewhere. Those coins won't move either. Really, just because a coin hasn't moved from its address for a while, that's no reason to assume its lost. Or, at the least, it would be very unwise for people to try to adjust value of the remaining coins, as those coins "lost" could move at any time. There's no proof the private keys for older coins have been lost, in many cases, no ones even claiming the key has beeen lost, it's just that someone is speculating that the key is lost due to the lack of movement.