there was not even a single case until now right?
Other than the successful double spend against OKPay which happened during the March 2013 fork (
link), I think the only other occasions where a double spend against an actual business was successful were the ones against SatoshiDice (
link) where it was possible to cancel out losing bets by double spending them while only letting winning bets go through.
If it's a reputable company i don't mind off-chain, see Coinbase. The good thing is with bitcoin people are free to choose.
I don't think it's really possible to know whether or not a company that offered such services was reputable unless they collapsed (at which point it would be too late, of course). Using the example of Inputs.io, TradeFortress was a highly trusted user here on the forums and his service claimed to have a very high standard of security - even going so far as to calling itself as "the most secure wallet ever created". Mt. Gox was the largest, and for a long time - the only, exchange in operation and that one also ended very badly for its customers.
Personally, I think it's best to consider all such services as being risky. However, if zero confirmation transactions aren't readily accepted by retailers due to the risk of fraud then I suppose they will become a necessary evil.